What should we know about MK677?

What should we know about MK677?

Ibutamoren MK677 is a non-peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including GH and insulin-like growth factor (IGF-1), but without affecting cortisol levels. MK677 has shown to sustain activation of GH-IGF-1 Axis and increase in lean body mass but no change in total fat mass or visceral fat. It is currently under development as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with growth hormone deficiency, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly.


Bodybuilders, athletes and strength trainers are always looking for ways that can help them to improve their performance and gain more muscles. Of course, there are many products out there that can help you achieve whatever you want, however many of these products have side effects that you definitely do not want to be a part of. Some of the most common side effects include high blood pressure, baldness, infertility and many other health related problems.

How does MK-677 work?

After ingestion, MK-677 signals the pituitary gland to secrete more growth hormone. In the next 24 hours after taking your dose, MK-677 will stimulate your pituitary gland to release over a dozen very strong GH pulses, which then stimulate the liver to produce Insulin-Like Growth Factor 1 (IGF-1).

How does MK-677 compare to injectable GH and peptides?

Studies show that the levels of IGF-1 in the blood of several different individuals taking MK-677 reach the equivalent of at least a 6-8 IU daily dose of growth hormone.

In contrast to peptides, MK-677 gives the same benefits but does not cause pituitary desensitization, does not need to be injected, and is cheaper.

What can I expect from MK-677 results wise?

Coupled with a decent diet and training regimen, you can expect a rapid increase in muscular fullness, size, strength, and overall performance.

Also, sleep quality is deeper and dramatically better, endurance is greatly enhanced during training sessions which means that your sports results will also improve.

Can MK-677 Suppress Your Natural GH Production?

MK-677 does not cause pituitary desensitization like other growth hormone releasing peptides do. Some of them, such as Hexarelin, begin to cause desensitization by the 2nd dose, and within a couple weeks are far less potent than they were the first time you injected them into your body.

MK-677 exhibits no such downside and the research actually has proved that MK-677 can become more effective with long-term use. One clinical study measured an increase in IGF-1 levels by 60% at the 6 month point and 72.9% after 12 months of treatment. As a result, your Natural GH production is entirely unaffected by MK-677 use.

Finally, here comes the very significant question: Are the gains from MK-677 maintainable after coming off of it?

Yes, the gains from MK-677 are very maintainable as it has no negative impact on your natural testosterone or natural GH production which secures the easy maintenance of your results as long as your diet and training plan are properly structures.

The aim of this article is not to persuade you into using this type of product. I have been following and reading all new information about peptides, SARMs and other products, which are becoming more and more popular and used abroad. Here, in Bulgaria, they are yet to start being used and the coaches and athletes are now learning how to take and combine them and what to expect from them. For writing this article, I used internet sources and the information contained in it is confirmed by at least 5 competent and authoritative magazines. The truth is that presently more and more tests with peptides and SARMs are being done and very soon, there will be official statements regarding their use in treatment and probably later in sports activities. Have in mind that a lot of such products of doubtful quality appeared on the market and they have nothing in common with the originals except the name. So do not throw yourself blindly into buying the magic pills. My advice is to emphasize on proper diet, training and recovery with the familiar, tested and safe – proved supplements.

This article has a purely informative character without stating any personal opinion about this product.

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